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              當(dāng)前位置:首頁(yè)技術(shù)文章WFS1抗原,Wolfram綜合征蛋白1抗原

              WFS1抗原,Wolfram綜合征蛋白1抗原

              更新時(shí)間:2024-11-14點(diǎn)擊次數(shù):47

              Recombinant human WFS1 protein   

              DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.     

              濃度:1mg/ ml

              來(lái)源:Recombinant Human

              純度:95% SDS-PAGE

              表達(dá)系統(tǒng):Escherichia coli

              標(biāo)簽:His tag   

              蛋白長(zhǎng)度:Full length protein

              內(nèi)毒素水平:<1.000 Eu/µg

              純化方法:HPLC

              應(yīng)用:SDS-PAGEWestern blotELISA

              Biological activity,immunology research

              保存:-20

              保質(zhì)期:1

              WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.



              產(chǎn)品名稱(chēng):Rabbit Anti-WFS1 protein antibody

              Rabbit Anti-WFS1 protein 

              別名:DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.                

              來(lái)源:Rabbit

              克隆類(lèi)型:Polyclonal

              濃度:1mg/ml

              亞型:IgG

              反應(yīng):Human (predicted: Mouse,Rat,Cow,Dog,Horse)

              應(yīng)用: WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

                     IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

              理論分子量:97kDa

              免疫原:KLH conjugated synthetic peptide derived from human WFS1 protein

              保存:-20
              保質(zhì)期:1

               

               

              產(chǎn)品名稱(chēng):Anti-WFS1 protein antibody

              Mouse Anti-WFS1 protein

              別名:DFNA14; DFNA38; DFNA6; DIDMOAD; WFRS; WFS; Wolfram syndrome 1 (wolframin); Wolfram syndrome; WOLFRAMIN; WFS1_HUMAN.                     

              來(lái)源:Mouse

              克隆類(lèi)型:Monoclonal

              濃度:1mg/ml

              亞型:IgG

              反應(yīng):Human

              應(yīng)用:WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500

                     IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500

              反應(yīng):  Human

              理論分子量:97kDa

              免疫原:KLH conjugated synthetic peptide derived from human WFS1 protein

              保存:-20
              保質(zhì)期:1

              Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).


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